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NAME: Karanjin

Molecular Formula: C18H12O4

Molecular Weight: 292.29 g/mol

Karanjin, a furanoflavonol, a type of flavonoid. It is obtained from the seeds of the karanja tree (Millettia pinnata, akaPongamia glabra Vent.), a tree growing wild in south India. Pongamia pinnata L. Pierre is a commonly used plant in traditional Indian medicinal systems.

Seeds are reported in Ayurveda and Siddha systems of medicine for treating bronchitis, chronic fever and rheumatism (Muthu et al., 2006). Extracts of seeds have been reported to possess anti-inflammatory (Singh and Pandey, 1996), anti-oxidative, analgesic, hypoglycaemic and anti-ulcerogenic properties (Dahanukar et al., 2000).

Seeds are reported as anthelmintic, and good in treatment of leprosy, piles, ulcers, chronic fever and in liver pain (Warrier et al., 1995). They are useful in rheumatism arthritis and scabies (Prasad and Reshmi, 2003) and to treat dermatitis of domestic animals (Sridhar, 2009).

Karanjin, a major bioactive furanoflavone of P. pinnata seeds is reported as Antioxidant, H+, K+ - ATPase inhibitor (Vismaya, 2010) and showed Anti-inflammatory activity in rats by inhibiting Lipoxygenase- 1 and 5- Lox (Sapna et al., 2007).

Karanjin is an Acaricide and Insecticide. Acaricide means a product that is used to kill mites (Acarina). Karanjin is used as bio pesticide / bio insecticide and is reported to have nitrification inhibitory properties

Flavonoids are widely distributed in plants functioning both as pigments and as means of chemical defense. In recent years, interest in the chemical biology of flavonoids has intensified in part due to the complex structural diversity within this class of natural product. This, combined with their generally-low cytotoxicity and unique activity, we have begun efforts to develop an understanding the pathways regulated by these materials. Karanjin represents one member of a large class of Benzofuran flavonoids. It has been identified in well over 50 plant species. While karanjin is an established Ascaracide and insecticide, little is known about its cellular function and molecular targets. In collaboration with a team at the Salk Institute, efforts


Product Name Karanj Seed Extract 75.0%
Botanical Name Millettia pinnata
Plant part Seeds
Standardization Karanjin
S. No. Parameters Specification Method
1 Description Off white to Pale yellow color powder Visual
2 Identification To comply by HPLC KVN/QC/STP-IN/011
3 Loss on drying NMT 5.0% USP <731>
4 Residue on Ignition NMT 5.0% USP <281>
5 Tapped bulk density 0.30-0.60g/ml USP <616>
Sieve test (passes through)
# 40 meshNLT 95.0%w/w
# 60 meshNLT 85.0%w/w
USP <786>
7 %Purity by HPLC
% Area of Karanjin

NLT 95.0%

8 %Assay By HPLC
Content of Karanjin

NLT 75.0% w/w on dry basis

Heavy Metals
LeadNMT 5.0ppmICP-OES
ArsenicNMT 1.0ppmICP-OES
CadmiumNMT 0.3ppmICP-OES
MercuryNMT 0.1ppmICP-OES
10 Residual solvents Should comply by ICH/USP USP <467>
Microbiological Profile
Total plate count NNMT 5000cfu/g USP <2021>
Yeast and molds count NMT 100cfu/g USP <2021>
Escherichia coli Absent /10g USP <2022>
Salmonella Absent /10g USP <2022>
Staphylococcus aureus Absent /10g USP <2022>
Pseudomonas aeruginosa Absent /10g USP <62>

We will provide the Spectral Data on Request