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NAME: Catechin hydrate [Acacia catechu extract]
Catechin is a polyphenolic flavonoid which has been isolated from a variety of natural sources including tea leaves, grape seeds, and the wood and bark of trees such as acacia and mahogany. Catechin has the ability to suppress the effects of Parkinson’s and Alzeimer’s disease. Catechin is a more potent antioxidant than ascorbate or α-tocopherol in certain in vitro assays of lipid peroxidation.
Potential Uses
Anti – obese:
Catechin hydratein diabetic rate has shown to be beneficial in reducing obesity and in improving plasma parameters. (Mehra 2010)
Anti – cancer activity:
Catechin hydrate, possesses anticancer activity is based on the ability to induce apoptosis. It also suppressed the growth of breast cancer cells without significant toxicity, making it a promising chemotherapeutic agent for breast cancer treatment (Ali A., 2010).
Catechin hydrate and HIV-1:
In a formulation study catechin hydrate has shown adjuvant effect in immune responses against the gp120 protein of HIV-1(CN54). Also in a combination of two mucosal and two systemic vaccinations of mice, the study has found significant enhancement of both local and systemic antibodies as well as cytokine responses.
PRODUCT SPECIFICATION
| QUALITY CONTROL DEPARTMENT | |
| Product Name | ChocoPure [Catechin] |
| Botanical Name | Acacia catechu |
| Plant part | Heart wood |
| Standardization | Catechin & Epicatechin |
| S. No. | Parameters | Specification | Method | ||||||||||||||||||
| Physical | |||||||||||||||||||||
| 1 | Description | White to Cream colored powder | Visual | ||||||||||||||||||
| 2 | Identification | To comply by HPLC | KVN/QC/STP-IN/007 | ||||||||||||||||||
| 3 | Loss on drying | NMT 5.0% | USP <731> | ||||||||||||||||||
| 4 | Residue on Ignition | NMT 3.0% | USP <281> | ||||||||||||||||||
| 5 | Solubility | Soluble in Water | KVN/QC/STP-GT/039 | ||||||||||||||||||
| 6 | Water by KF | NMT 5.0% w/w | USP<921> | ||||||||||||||||||
| 7 | Tapped bulk density | 0.30-0.50 g/ml | USP <616> | ||||||||||||||||||
| Sieve test (passes through) | |||||||||||||||||||||
| 8 | # 20 mesh | NLT 95.0%w/w | USP <786> | ||||||||||||||||||
| Chemical | |||||||||||||||||||||
| 9 |
Purity by HPLC [% Areas of Catechin & Epicatechin] |
NLT 95.0% Purity on dry basis | KVN/QC/STP-IN/007 | ||||||||||||||||||
| 10 | Assay By HPLC Content of Catechin Content of Epictechin |
50.0 - 60.0% w/w on dry basis 15.0 -20.0% w/w on dry basis |
KVN/QC/STP-IN/007 |
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| Others | |||||||||||||||||||||
| 11 |
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| 12 | Residual solvents | Should comply by ICH/USP | USP <467> | ||||||||||||||||||
| Microbiological Profile | |||||||||||||||||||||
| 13 |
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